This experiment focused on Huntingtons disease, a genetic neurodegenerative disorder. cellular activity creates free radicals, which create oxidation in cells. Huntingtons disease causes a specific gene sequence to repeating too many times, thus creating an increase in cellular activity; however the ultimate cause of neuronal dying is oxidation. In rodents used for scientific experimentation, the goal is to induce symptoms mistakable to that of Huntingtons disease by using specific neurotoxins. 3-nitropropionic acid (3-np) has been found to produce symptoms most similar to Huntingtons disease.
3-np disrupts the function of mitochondria in cells, which results in an increase of oxidative stress. Extra virgin olive oil contains monounsaturated acids, which have a counteractive inwardness on the oxidative stress of neurons in the brain.
40 rats were isolated into groups, some of which were injected with 3-np and given extra virgin olive oil via a gastric catheter. The rats that were given 3-np experienced increased oxidation of their striatum and brain. Those negative changes were significantly reduced by former and concurrent injections of extra virgin olive oil and hydroxytyrosol. De la Torre et el say that, This study showed that EVOO and HT exerted strong antioxidative effects in a 3NP-induced HD-like animal model, as well as a similar...If you want to get a full essay, order it on our website: Ordercustompaper.com
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